The Escape is the fifty-forth episode of the anime.
Tenma and Gunther Milch plan to escape with the help of Gunther's brother, Gustav. Gustav is supossed to fake an accident, so the van transporting Tenma and Gustav stops and they can escape. Nevertheless, the plan goes wrong and Gustav is run over by the van and almost dies.
The guards ask Tenma to check on Gustav to see if his is alive or not. While checking Gustav, Tenma notices that he is carrying a gun and manages to grab it, then points the gun at the guards and orders them to free them.
Eva gets ready to meet attorney Alfred Baul in the lobby of the hotel when she learns from the TV news that Tenma has escaped. While sitting, Eva listens to Roberto's voice while he is talking on the phone with Verdemann about Tenma's escape. Frightened, Eva runs to her room. There, she sees a cigarette butt in the ashtray and realizes that Roberto was in the room.
Tenma suggests driving Gustav to an hospital in order to save his life, but Gunther refues, arguing that there s no time for that. Tenma points his gun to Gunther and forces him to drive to Eisler Memorial Hospital. Once there, Tenma and Gunther get down from the car and Tenma tells Helene, Gustav's girlfriend, to drive inside and give a letter that he has written with details of the accident to Dr. Wagner. Tenma and Gunther part ways.
Someone knocks at Eva's hotel room door, she stands up and slowly opens the door, nervously.